Learning to optimize has emerged as a powerful framework for various optimization and machine learning tasks. Current such “meta-optimizers” often learn in the space of continuous optimization algorithms that are point-based and uncertainty- unaware. To overcome the limitations, we propose a meta-optimizer that learns in the algorithmic space of both point-based and population-based optimization algorithms. The meta-optimizer targets at a meta-loss function consisting of both cumulative regret and entropy. Specifically, we learn and interpret the update formula through a population of LSTMs embedded with sample- and feature-level attentions. Meanwhile, we estimate the posterior directly over the global optimum and use an uncertainty measure to help guide the learning process. Empirical results over non-convex test functions and the protein-docking application demonstrate that this new meta-optimizer outperforms existing competitors. The codes are publicly available at: https://github.com/Shen-Lab/LOIS.